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DTSTART;TZID=Australia/Sydney:20260928T130000
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SUMMARY:Powerful and accurate case-control analysis of spatial molecular data
DESCRIPTION:Statistical Bioinformatics SeminarSpeaker: Dr Yakir Reshef\, Harvard Medical School \n\n\n\nThis is an online event held via Zoom: https://uni-sydney.zoom.us/j/85114748391 \n\n\n\n\n\n\n\n\n\nAs spatial molecular data grow in scope\, there is a pressing need to identify disease-associated spatial structures. Current approaches typically make restrictive assumptions such as representing tissue regions by abundances of discrete cell types and samples by abundances of discrete niches; this risks overlooking important signals. I will discuss variational inference-based microniche analysis (VIMA)\, a method combining deep learning with principled statistics to discover disease-associated spatial features with greater flexibility and precision. VIMA trains an ensemble of variational autoencoders to summarize the contents of every small tissue patch in a dataset via numeric “fingerprints”. It uses these to define many data-dependent\, overlapping “microniches” and meta-analyzes them to identify microniches whose abundance correlates significantly with case-control status. After describing the method\, I’ll show how it performs in simulations designed to assess calibration\, power\, and spatial accuracy. I’ll then give some examples of how we have used VIMA on spatial datasets from diverse spatial modalities\, where it recapitulates known biology and identifies novel spatial features of disease. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nDr Yakir Reshef\n\n\n\nYakir Reshef completed his undergraduate training in mathematics at Harvard College and subsequently completed a Fulbright in probability theory followed by a PhD in computer science at Harvard University and an MD from Harvard Medical School. He is currently a faculty member at Harvard Medical School and Brigham and Women’s Hospital\, where his group focuses on developing and applying new methods to achieve a quantitative understanding of inflammation and auto-immunity from high-dimensional molecular data such as single-cell and spatial transcriptomics data. He is also clinically active\, treating patients with autoimmune disease as a rheumatologist. \n\n\n\nConnect with Yakir:X: @YakirReshefBluesky: @yakirreshef.bsky.social
URL:https://spds.sydney.edu.au/event/powerful-and-accurate-case-control-analysis-of-spatial-molecular-data/
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DTSTART;TZID=Australia/Sydney:20261015T110000
DTEND;TZID=Australia/Sydney:20261015T120000
DTSTAMP:20260909T020338Z
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SUMMARY:Charles Perkins Centre Data Science Hub - Introduction and Showcase
DESCRIPTION:This event is in-person only and requires registration. \n\n\n\n\n\n\n\nJoin us as we introduce the Charles Perkins Centre Data Science Hub and showcase our first projects.Discover how the Data Science Hub’s collaborative platform advances data-intensive research\, builds capacity and shares knowledge. The event will highlight key achievements from projects of varying scale and share our vision to support EMCRs and accelerate research translation.We invite you to meet our data scientists\, explore opportunities for collaboration\, and discover how to engage with us.  Refreshments will be provided. \n\n\n\n\n\n\n\nThe Data Science Hub is a collaborative partnership with the Charles Perkins Centre and Sydney Precision Data Science Centre\, co-funded by the Charles Perkins Centre’s Jennie Mackenzie Research Fund\, the Faculty of Medicine and Health and Faculty of Science.  The Data Science Hub advances data-intensive research with a direct translational impact in biomedical\, metabolomics health\, epidemiological research\, and beyond. We specialise in context-specific data analysis for high-throughput biomedical data generated by scientists.
URL:https://spds.sydney.edu.au/event/charles-perkins-centre-data-science-hub-introduction-and-showcase/
LOCATION:Jennie Mackenzie Room\, Level 6\, Charles Perkins Centre\, Johns Hopkins Drive\, University of Sydney\, Camperdown NSW 2006\, Sydney\, 2006\, Australia
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