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DTSTART;TZID=Australia/Sydney:20260831T130000
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SUMMARY:Illuminating the dark proteome: Insights from RNA translation in health and disease
DESCRIPTION:Statistical Bioinformatics SeminarSpeaker: Dr Sonia Chothani\, Genome Institute of Singapore \n\n\n\nThis is an online event held via Zoom: https://uni-sydney.zoom.us/j/85114748391 \n\n\n\n\n\n\n\n\n\nRNA translation is a fundamental process in gene expression\, yet its extent\, role and regulation in human diseases remain unclear. In my talk\, I will describe how our data-driven approaches to study RNA translation have revealed a substantial portion of gene expression activity that has been overlooked when studying diseases. This has led to 1) a paradigm shift in that human transcripts often translate multiple distinct open reading frames (ORFs)\, 2) a 40% increase in translated ORFs encoded in the human genome including within lncRNAs and 3) detection of widespread gene expression changes that were previously missed in traditional RNA-based target discovery screens. These findings highlight a largely untapped search-space for new biomarkers\, therapeutic targets and antigens for targeted therapy. Additionally\, the algorithms developed provide a powerful platform to gain insights on the translatome in any given system\, as demonstrated by our work in fibrosis\, inflammation\, and cancer\, paving the way for future breakthroughs in RNA biology. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nDr Sonia Chothani\n\n\n\nDr Sonia Chothani is a Principal Investigator at the Genome Institute of Singapore\, A*STAR\, Singapore. She holds a B.Tech in Biotechnology from IIT Madras and an M.S. in Computational Biology from Carnegie Mellon University and a Ph.D. in Integrated Biology and Medicine at Duke-NUS medical school\, where she specialized in RNA translation and its regulation in cardiac fibrosis. She holds 3 patents and has published >35 papers (h-index 18) in journals such as Circulation\, Molecular Cell\, Nature\, and Science Translational Medicine. Through an interdisciplinary approach that combines computational and experimental biology\, her lab aims to translate fundamental discoveries in RNA translation biology into new opportunities for cancer treatment. \n\n\n\nConnect with Sonia:https://www.linkedin.com/in/sonia-chothani-b192b515/
URL:https://spds.sydney.edu.au/event/illuminating-the-dark-proteome-insights-from-rna-translation-in-health-and-disease/
ATTACH;FMTTYPE=image/jpeg:https://spds.sydney.edu.au/wp-content/uploads/2025/02/Complex-systems-1-edited-scaled.jpeg
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DTSTART;TZID=Australia/Sydney:20260907T130000
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DTSTAMP:20260824T002437Z
CREATED:20260823T235037Z
LAST-MODIFIED:20260824T002437Z
UID:5463-1788786000-1788789600@spds.sydney.edu.au
SUMMARY:Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors
DESCRIPTION:Statistical Bioinformatics SeminarSpeaker: Dr Guolan Lu\, Stanford University \n\n\n\nThis is an online event held via Zoom: https://uni-sydney.zoom.us/j/85114748391 \n\n\n\n\n\n\n\n\n\nThe development of effective antibody therapeutics has been hampered by a lack of methods to measure drug delivery and activity within tumors at single-cell resolution. Here we introduce single-cell spatial pharmacobiology (SSP)\, an experimental and analytical framework that integrates in situ imaging of a systemically infused\, fluorescently labeled therapeutic antibody with high-plex spatial proteomics to quantify antibody distribution\, target engagement and tumor microenvironment (TME) architecture. We applied SSP to tumor tissues from participants with head and neck squamous cell carcinoma and pancreatic ductal adenocarcinoma who received the antibody panitumumab-IRDye800 in phase 1 trials. SSP identified pronounced spatial heterogeneity in single-cell drug delivery and target engagement\, shaped by conserved stromal barriers\, including periostin-rich extracellular matrix assemblies and fibroblast-activation-protein-positive cancer-associated fibroblast neighborhoods\, which were associated with reduced antibody delivery in both tumor types. SSP measures drug–target–TME interactions in human tumors and can support studies of resistance mechanisms\, dosing strategies and discovery of spatial biomarkers for precision oncology. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nDr Guolan Lu\n\n\n\nGuolan Lu is a tenure-track Assistant Professor at Stanford University. Her laboratory develops spatial multi-omics and artificial intelligence technologies to determine how tissue organization shapes disease progression and therapeutic response. During her postdoctoral training at Stanford with Eben Rosenthal and Garry Nolan\, she designed and led a first-in-human fluorescence-guided surgery study in pancreatic cancer and pioneered single-cell spatial pharmacobiology in human tumors. She received her PhD through the joint Biomedical Engineering program at Georgia Tech and Emory University. \n\n\n\nConnect with Guolan:X: @GuolanLu
URL:https://spds.sydney.edu.au/event/single-cell-spatial-pharmacobiology-identifies-conserved-stromal-barriers-to-therapeutic-antibody-delivery-in-human-solid-tumors/
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