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DTSTART;TZID=Australia/Sydney:20260921T130000
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SUMMARY:STORM: Unified spatial\, temporal\, and multimodal data integration into biologically interpretable embeddings
DESCRIPTION:Statistical Bioinformatics SeminarSpeaker: Xinyi Lisa Chen\, Yale University \n\n\n\nThis is an online event held via Zoom: https://uni-sydney.zoom.us/j/85114748391 \n\n\n\n\n\n\n\n\n\nSpatiotemporal multi-omic atlases are rapidly emerging and shifting tissue biology from static\, single-modality snapshots to dynamic\, multi-layer atlases across development and disease. Yet integrating space\, time\, and modality while preserving tissue geometry\, transient niches\, and real biological change remains difficult. Here we introduce STORM (Spatial Temporal multi-Omics Representation Model)\, among the first end-to-end frameworks to jointly model space–time–modality while grounding the representation in gene programs. STORM learns a unified cell embedding using a multimodal graph neural network variational autoencoder\, jointly aligning timepoints and modalities while correcting time-dependent technical variation. Leveraging curated gene programs\, STORM decomposes complex biology into interpretable\, program-level components across modalities and reveals time-evolving program dynamics. STORM extends to multiple timepoints\, sequencing platforms\, tissues\, and biological conditions\, as demonstrated in three paired spatial RNA–ATAC datasets spanning postnatal (P0–P22) and embryonic (E11.0–E18.5) mouse brain development and a lysolecithin-induced demyelination model. Across datasets\, STORM preserves stage-dependent anatomy\, resolves small anatomically meaningful populations (including the island of Calleja)\, tracks coordinated spatiotemporal program trajectories\, and enables program-level RNA–ATAC contrasts that expose regulatory priming not apparent from expression alone. Our results demonstrate that STORM provides a scalable\, interpretable route to dissect spatiotemporal molecular programs from time-course spatial multi-omic data. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nXinyi Lisa Chen\n\n\n\nXinyi Lisa Chen is a Ph.D. candidate in Computational Biology and Biomedical Informatics at Yale University\, advised by Professor Hongyu Zhao. Before Yale\, she earned her bachelor’s degree in Computer Science and Statistics from the University of Toronto. Her research develops interpretable machine learning methods for spatial and perturbational multi-omics data\, with the broader goal of building computational models of a “virtual cell in tissue.” She is the lead developer of STORM\, a graph-based generative framework that integrates spatial context\, developmental time\, and multi-modal measurements (e.g. RNA and ATAC) into biologically interpretable gene-program representations. She has also led multimodal single-cell analyses of cellular and regulatory changes across prodromal and early Parkinson’s disease. More recently\, Lisa has expanded her work to scientific AI agents\, studying reliable tool use\, long-horizon evaluation\, experience memory reuse\, and failure monitors for AI agents.  \n\n\n\nConnect with Xinyi Lisa:LinkedIn: www.linkedin.com/in/xinyi-lisa-chen-yale
URL:https://spds.sydney.edu.au/event/storm-unified-spatial-temporal-and-multimodal-data-integration-into-biologically-interpretable-embeddings/
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