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SUMMARY:Illuminating the dark proteome: Insights from RNA translation in health and disease
DESCRIPTION:Statistical Bioinformatics SeminarSpeaker: Dr Sonia Chothani\, Genome Institute of Singapore \n\n\n\nThis is an online event held via Zoom: https://uni-sydney.zoom.us/j/85114748391 \n\n\n\n\n\n\n\n\n\nRNA translation is a fundamental process in gene expression\, yet its extent\, role and regulation in human diseases remain unclear. In my talk\, I will describe how our data-driven approaches to study RNA translation have revealed a substantial portion of gene expression activity that has been overlooked when studying diseases. This has led to 1) a paradigm shift in that human transcripts often translate multiple distinct open reading frames (ORFs)\, 2) a 40% increase in translated ORFs encoded in the human genome including within lncRNAs and 3) detection of widespread gene expression changes that were previously missed in traditional RNA-based target discovery screens. These findings highlight a largely untapped search-space for new biomarkers\, therapeutic targets and antigens for targeted therapy. Additionally\, the algorithms developed provide a powerful platform to gain insights on the translatome in any given system\, as demonstrated by our work in fibrosis\, inflammation\, and cancer\, paving the way for future breakthroughs in RNA biology. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nDr Sonia Chothani\n\n\n\nDr Sonia Chothani is a Principal Investigator at the Genome Institute of Singapore\, A*STAR\, Singapore. She holds a B.Tech in Biotechnology from IIT Madras and an M.S. in Computational Biology from Carnegie Mellon University and a Ph.D. in Integrated Biology and Medicine at Duke-NUS medical school\, where she specialized in RNA translation and its regulation in cardiac fibrosis. She holds 3 patents and has published >35 papers (h-index 18) in journals such as Circulation\, Molecular Cell\, Nature\, and Science Translational Medicine. Through an interdisciplinary approach that combines computational and experimental biology\, her lab aims to translate fundamental discoveries in RNA translation biology into new opportunities for cancer treatment. \n\n\n\nConnect with Sonia:https://www.linkedin.com/in/sonia-chothani-b192b515/
URL:https://spds.sydney.edu.au/event/illuminating-the-dark-proteome-insights-from-rna-translation-in-health-and-disease/
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