BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Sydney Precision Data Science Centre - ECPv6.15.18//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Sydney Precision Data Science Centre
X-ORIGINAL-URL:https://spds.sydney.edu.au
X-WR-CALDESC:Events for Sydney Precision Data Science Centre
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:Australia/Sydney
BEGIN:STANDARD
TZOFFSETFROM:+1100
TZOFFSETTO:+1000
TZNAME:AEST
DTSTART:20240406T160000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+1000
TZOFFSETTO:+1100
TZNAME:AEDT
DTSTART:20241005T160000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+1100
TZOFFSETTO:+1000
TZNAME:AEST
DTSTART:20250405T160000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+1000
TZOFFSETTO:+1100
TZNAME:AEDT
DTSTART:20251004T160000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:+1100
TZOFFSETTO:+1000
TZNAME:AEST
DTSTART:20260404T160000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:+1000
TZOFFSETTO:+1100
TZNAME:AEDT
DTSTART:20261003T160000
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=Australia/Sydney:20251020T130000
DTEND;TZID=Australia/Sydney:20251020T140000
DTSTAMP:20260407T055641
CREATED:20251013T013941Z
LAST-MODIFIED:20251013T013957Z
UID:4222-1760965200-1760968800@spds.sydney.edu.au
SUMMARY:High-resolution Characterization of Age-specific Changes in HPV-negative HNSCC through Building a scRNA-Sequencing Atlas
DESCRIPTION:Statistical Bioinformatics SeminarLina Kroehling\, Boston University\n\n\n\nThis is an online event held via Zoom: https://uni-sydney.zoom.us/j/85114748391 \n\n\n\n\n\n\n\n\n\nAge is strongly associated with both the incidence and mortality risk of head and neck cancer. While cancer and aging share many of their defining “hallmarks”\, including chronic inflammation\, increased genomic instability\, and increased senescence\, more research is needed to elucidate the specific mechanisms contributing to cancer aggressiveness in older patients. \n\n\n\nTo this end\, we have assembled a hiqh-quality human single-cell RNA-sequencing HNSCC atlas profiling more than 290\,000 cells across more than 70 patients\, with ages ranging between 18 and 90\, which provides a unique resource to investigate age-associated changes in the disease’s heterogeneity.  \n\n\n\nTo create the atlas\, we integrated seven publicly available single-cell RNAseq datasets from 73 HPV-negative patients. Cells were clustered\, classified\, and characterized by gene set enrichment analysis\, both in the epithelial cell compartment and in the tumor microenvironment (TME). Differential expression and cell type proportion analyses were performed to identify genes and cell type compositional changes associated with age. Cell cell communication analysis was performed to identify interacting cell types and modeled to identify specific ligands and receptors changing with age. \n\n\n\nWe identified distinct age-related changes in cell type composition\, including vascular endothelial cells increasing with age\, and several tumor clusters with distinct functions also changing with age. Further analyses are ongoing\, and we plan to functionally validate the hypotheses generated\, specifically the presence of differentially abundant cell populations\, and age-specific ligand-receptor signaling events that contribute to tumor growth. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nLina Kroehling\n\n\n\nLina Kroehling is a bioinformatics PhD candidate in the Monti Lab at Boston University where she utilizes multi-omics data to study Head and Neck Cancer. She has a B.S. and M.S. in biochemistry from Clark University in Worcester MA\, and worked as a bioinformatician in academic immunology labs before starting her PhD. 
URL:https://spds.sydney.edu.au/event/high-resolution-characterization-of-age-specific-changes-in-hpv-negative-hnscc-through-building-a-scrna-sequencing-atlas/
ATTACH;FMTTYPE=image/jpeg:https://spds.sydney.edu.au/wp-content/uploads/2025/02/Complex-systems-1-edited-scaled.jpeg
END:VEVENT
END:VCALENDAR