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DTSTART;TZID=Australia/Sydney:20250915T130000
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CREATED:20250718T043847Z
LAST-MODIFIED:20250922T070523Z
UID:3943-1757941200-1757944800@spds.sydney.edu.au
SUMMARY:Bifidobacteria support optimal infant vaccine responses
DESCRIPTION:Statistical Bioinformatics SeminarDr Feargal J. Ryan\, Flinders University\n\n\n\nThis was an online event held via Zoom. \n\n\n\n\n\n\n\n\n\n\n\nAccumulating evidence indicates that antibiotic exposure may lead to impaired vaccine responses; however\, the mechanisms underlying this association remain poorly understood. Here we prospectively followed 191 healthy\, vaginally born\, term infants from birth to 15 months\, using a systems vaccinology approach to assess the effects of antibiotic exposure on immune responses to vaccination. Exposure to direct neonatal but not intrapartum antibiotics was associated with significantly lower antibody titres against various polysaccharides in the 13-valent pneumococcal conjugate vaccine and the Haemophilus influenzae type b polyribosylribitol phosphate and diphtheria toxoid antigens in the combined 6-in-1 Infanrix Hexa vaccine at 7 months of age. Blood from infants exposed to neonatal antibiotics had an inflammatory transcriptional profile before vaccination; in addition\, faecal metagenomics showed reduced abundance of Bifidobacterium species in these infants at the time of vaccination\, which was correlated with reduced vaccine antibody titres 6 months later. In preclinical models\, responses to the 13-valent pneumococcal conjugate vaccine were strongly dependent on an intact microbiota but could be restored in germ-free mice by administering a consortium of Bifidobacterium species or a probiotic already widely used in neonatal units. Our data suggest that microbiota-targeted interventions could mitigate the detrimental effects of early-life antibiotics on vaccine immunogenicity. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nDr Feargal J. Ryan\n\n\n\nDr Feargal J. Ryan is an NHMRC Investigator and head of the Computational Multi-Omics Group at Flinders University. He specializes in systems biology\, bioinformatics and the use of multi-omics data to study molecular mechanisms of health and disease in humans. Dr Ryan has co-authored over 45 peer reviewed papers including in top journals such as Nature and Science\, which have spanned the human microbiome\, idiopathic diseases\, infection and cancer. He is also an advocate for supporting bioinformatics research in Australia and last year was elected as Vice-President of the national Australian Bioinformatics and Computational Biology Society (ABACBS). 
URL:https://spds.sydney.edu.au/event/bifidobacteria-support-optimal-infant-vaccine-responses/
ATTACH;FMTTYPE=image/jpeg:https://spds.sydney.edu.au/wp-content/uploads/2025/02/Complex-systems-1-edited-scaled.jpeg
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