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DTSTART;TZID=Australia/Sydney:20250428T130000
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SUMMARY:Spatially resolved mapping of cells associated with human complex traits
DESCRIPTION:Liyang Song\, Westlake University\n\n\n\n\n\n\n\n\n\nDepicting spatial distributions of disease-relevant cells is crucial for understanding disease pathology. In our recent work\, we developed a method\, gsMap\, that integrates spatial transcriptomics (ST) data with genome-wide association study (GWAS) summary statistics to map cells to human complex traits\, including diseases\, in a spatially resolved manner. Using embryonic ST datasets covering 25 organs\, we benchmarked gsMap through simulation and by corroborating known trait-associated cells or regions in various organs. Applying gsMap to brain ST data\, we revealed that the spatial distribution of glutamatergic neurons (glu-neurons) associated with schizophrenia more closely resembles that for cognitive traits than that for mood traits\, such as depression. The schizophrenia-associated glu-neurons were distributed near the dorsal hippocampus\, with upregulated calcium signaling and regulation genes\, while the depression-associated glu-neurons were distributed near the deep medial prefrontal cortex\, with upregulated neuroplasticity and psychiatric drug target genes. \n\n\n\n\n\n\nSubscribe to our seminar mailing list\n\n\n\n\n→\n\n\n\n\n\n\n\nFind out more about the Statistical Bioinformatics seminar series\n\n\n\n\n\n→\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nLiyang Song\n\n\n\nLiyang Song is a fourth-year Ph.D. student in Statistical Genetics at Westlake University\, advised by Dr. Jian Yang. His research focuses on the intersection of human genetics\, statistics\, deep learning\, and spatial omics\, with applications to medicine. He is dedicated to developing efficient statistical methods and software tools that enable robust genetic and scientific discoveries by integrating genetic data with multi-omics datasets.
URL:https://spds.sydney.edu.au/event/spatially-resolved-mapping-of-cells-associated-with-human-complex-traits/
ATTACH;FMTTYPE=image/jpeg:https://spds.sydney.edu.au/wp-content/uploads/2025/02/Complex-systems-1-edited-scaled.jpeg
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