Through the Unlabeled Lens of Spatial Multi-Omics

Sometimes it matters less what you look at, and more what you see. Common practices in clinical pathology often involve multiple histological stains on serial sections of tissue biopsy to obtain the highest diagnostic power, but this requires expertise, reagent costs, consumes tissue, risks deformation, and complicates co-registration, potentially missing rare microstructures. Now there is a major push for spatial multi-omics integration, but even adjacent tissue sections captured with different modalities decrease performance. Today’s seminar introduces a non-destructive label-free optical platform combining SRS, SHG, and TPF enables high-resolution molecular imaging to unravel the lipidomic, metabolic, and morphometric landscape of kidney disease, and how these data types can augment your modalities.