Incorporating experimental medicine into single-cell multi-omics

About the seminar:
Coordinated global efforts to create a comprehensive map of the human body using single-cell technologies has opened up avenues in computational biology and AI. However, there remains a pressing need to increase the data diversity from the ancestral diversity of participants to increasing the types of immune perturbations captured. This talk will focus on incorporating single-cell multi-omics to different experimental medicine approaches–such as deceased organ donors, vaccine and xenogeneic-antigen challenge trials–in order to understand healthy immune responses in lymphoid organs.

About the speaker: Jacqueline Siu received her PhD at the University of Cambridge where she combined bioinformatics and experimental medicine to understand the function and differentiation of homeostatic human B cells in matched secondary lymphoid organs. To extend her interest in human tissue immunity especially after perturbation, Jacqueline joined the labs of Professor Mark Coles/ Professor Calliope Dendrou as a postdoctoral fellow, where she explored the influenza vaccine response of human axillary lymph nodes. In 2023, Jacqueline received the Wellcome Trust Early Career award to continue her interest in integrating human challenge models and single-cell genomics to understand early responding human B cells and their impact on long-lived antibodies.